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Zegers had previously worked with co-star Yasmine Bleeth in the 1999 film It Came From the Sky.
After appearing in the remake of Dawn of the Dead, he had a major role in the Academy Award-nominated independent film Transamerica (2005), costarring Felicity Huffman.
As payback, Woody (in Nell's body) dresses in inappropriate and provocative clothing the following day.
After school, Nell (in Woody's body), in retaliation, breaks up with Breanna (Brooke D'Orsay), Woody's girlfriend, much to the disappointment of Woody.
Zegers' performance as the street hustling bisexual son of a male-to-female transsexual was praised by several critics, and he won the 2006 Cannes Film Festival Chopard Award, which is given to promising young actors.
It's a Boy Girl Thing was produced by Elton John's motion picture company Rocket Pictures and independently distributed by Mel Gibson's Icon Productions and was released on 26 December 2006 in the UK and has since then been released in some countries in cinemas, in others directly to DVD, and in others as a TV film.
Most of the school scenes were shot at Western Technical-Commercial School in Toronto, Ontario, Canada.
Woody Deane (Kevin Zegers) and Nell Bedworth (Samaire Armstrong) are neighbors and former childhood friends who go to the same high school, but are otherwise completely different.
At first, they seem to succeed, but quickly return to arguing when they each feel the other is misrepresenting them in the opposite body, such as Woody (in Nell's body) answering a question oddly and surprising a teacher.
The following day, Nell (in Woody's body) arrives at school wearing "Chinos and an Oxford cotton button-down" making Woody's appearance look "dorky" which frustrates Woody, and he is even more frustrated after he hears about how Nell (in Woody's body) failed Woody's football practice the previous day.